The linker histone plays a dual role during gametogenesis in Saccharomyces cerevisiae.

@article{Bryant2012TheLH,
  title={The linker histone plays a dual role during gametogenesis in Saccharomyces cerevisiae.},
  author={Jessica M. Bryant and J{\'e}r{\^o}me Govin and Liye Zhang and Greg Donahue and B. Franklin Pugh and Shelley L Berger},
  journal={Molecular and cellular biology},
  year={2012},
  volume={32 14},
  pages={2771-83}
}
The differentiation of gametes involves dramatic changes to chromatin, affecting transcription, meiosis, and cell morphology. Sporulation in Saccharomyces cerevisiae shares many chromatin features with spermatogenesis, including a 10-fold compaction of the nucleus. To identify new proteins involved in spore nuclear organization, we purified chromatin from mature spores and discovered a significant enrichment of the linker histone (Hho1). The function of Hho1 has proven to be elusive during… CONTINUE READING
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