The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity

  title={The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity},
  author={Cristina Morales Torres and Alva Biran and Matthew J. Burney and Harshil Patel and Tristan Henser-Brownhill and Ayelet-Hashahar Shapira Cohen and Yilong Li and Rotem Ben-Hamo and Emma Nye and Bradley Spencer-Dene and Probir Chakravarty and Sol Efroni and N. D. Matthews and Tom Misteli and Eran Meshorer and Paola Scaffidi},
Tumors comprise functionally diverse subpopulations of cells with distinct proliferative potential. Here, we show that dynamic epigenetic states defined by the linker histone H1.0 determine which cells within a tumor can sustain the long-term cancer growth. Numerous cancer types exhibit high inter- and intratumor heterogeneity of H1.0, with H1.0 levels correlating with tumor differentiation status, patient survival, and, at the single-cell level, cancer stem cell markers. Silencing of H1.0… CONTINUE READING
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