The link between the PDL1 costimulatory pathway and Th17 in fetomaternal tolerance.

@article{DAddio2011TheLB,
  title={The link between the PDL1 costimulatory pathway and Th17 in fetomaternal tolerance.},
  author={Francesca D'Addio and Leonardo V Riella and Bechara G. Mfarrej and Lola Chabtini and La Tonya Adams and Melissa E Yeung and H. Yagita and Miyuki Azuma and Mohamed H. Sayegh and Indira Guleria},
  journal={Journal of immunology},
  year={2011},
  volume={187 9},
  pages={4530-41}
}
Fetomaternal tolerance has been shown to depend both on regulatory T cells (Tregs) and negative signals from the PD1-PDL1 costimulatory pathway. More recently, IL-17-producing T cells (Th17) have been recognized as a barrier in inducing tolerance in transplantation. In this study, we investigate the mechanisms of PDL1-mediated regulation of fetomaternal tolerance using an alloantigen-specific CD4(+) TCR transgenic mouse model system (ABM-tg mouse). PDL1 blockade led to an increase in embryo… CONTINUE READING

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