• DOI:10.1007/s00213-014-3523-4
• Corpus ID: 15229844

The link between dopamine function and apathy in cannabis users: an [18F]-DOPA PET imaging study

@article{Bloomfield2014TheLB,
  title={The link between dopamine function and apathy in cannabis users: an [18F]-DOPA PET imaging study},
  author={Michael A.P. Bloomfield and Celia J. A. Morgan and Shitij Kapur and H. Valerie Curran and Oliver D. Howes},
  journal={Psychopharmacology},
  year={2014},
  volume={231},
  pages={2251-2259}
}

• M. Bloomfield, C. Morgan, +2 authors O. Howes
• Published 3 April 2014
• Psychology
• Psychopharmacology

RationaleCannabis is the most widely used illicit drug in the world, and regular use has been associated with reduced motivation, i.e. apathy. Regular long-term cannabis use has been associated with reduced dopamine synthesis capacity. The mesolimbic dopaminergic system mediates the processing of incentive stimuli by modifying their motivational value, which in turn is modulated by endocannabinoid signalling. Thus, it has been proposed that dopaminergic dysfunction underlies the apathy associated with chronic cannabis use.ObjectivesThe aim of this study was to examine the relationship between dopaminergic function and subjective apathy in cannabis users.MethodsWe measured dopamine synthesis capacity (indexed as the influx rate constant Kicer) via 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine positron emission tomography and subjective apathy using the self-rated Apathy Evaluation Scale (AES-S) in 14 regular cannabis users.ResultsAll subjects scored in excess of 34 points on the AES-S (median [interquartile range] 59.5 [7.5]), indicative of significant apathy based on normative data. Kicer was inversely correlated to AES-S score in the whole striatum and its associative functional subdivision (Spearman’s rho = −0.64, p = 0.015 [whole striatum]; rho = −0.69, p = 0.006 [associative]) but not in the limbic or sensorimotor striatal subdivisions. There were no significant relationships between AES-S and current cannabis consumption (rho = 0.28, p = 0.34) or age of first cannabis use (rho = 0.25, p = 0.40).ConclusionsThese findings indicate that the reduction in striatal dopamine synthesis capacity associated with chronic cannabis use may underlie reduced reward sensitivity and amotivation associated with chronic cannabis use.