The link between dopamine function and apathy in cannabis users: an [18F]-DOPA PET imaging study

@article{Bloomfield2014TheLB,
  title={The link between dopamine function and apathy in cannabis users: an [18F]-DOPA PET imaging study},
  author={Michael A.P. Bloomfield and Celia J. A. Morgan and Shitij Kapur and H. Valerie Curran and Oliver D. Howes},
  journal={Psychopharmacology},
  year={2014},
  volume={231},
  pages={2251-2259}
}
RationaleCannabis is the most widely used illicit drug in the world, and regular use has been associated with reduced motivation, i.e. apathy. Regular long-term cannabis use has been associated with reduced dopamine synthesis capacity. The mesolimbic dopaminergic system mediates the processing of incentive stimuli by modifying their motivational value, which in turn is modulated by endocannabinoid signalling. Thus, it has been proposed that dopaminergic dysfunction underlies the apathy… 
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