The link between childhood trauma and depression: Insights from HPA axis studies in humans

@article{Heim2008TheLB,
  title={The link between childhood trauma and depression: Insights from HPA axis studies in humans},
  author={Christine Heim and Donald Jeffrey Newport and Tanja C Mletzko and Andrew H Miller and Charles B. Nemeroff},
  journal={Psychoneuroendocrinology},
  year={2008},
  volume={33},
  pages={693-710}
}
Childhood trauma is a potent risk factor for developing depression in adulthood, particularly in response to additional stress. We here summarize results from a series of clinical studies suggesting that childhood trauma in humans is associated with sensitization of the neuroendocrine stress response, glucocorticoid resistance, increased central corticotropin-releasing factor (CRF) activity, immune activation, and reduced hippocampal volume, closely paralleling several of the neuroendocrine… Expand
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