The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation

@inproceedings{Rodgers2014TheLU,
  title={The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation},
  author={Mary A Rodgers and James W. Bowman and Hiroaki Fujita and Nicole I. Orazio and Mude Shi and Qiming Liang and Rina Amatya and Thomas B Kelly and Kazuhiro Iwai and Jenny P-Y Ting and Jae U Jung},
  booktitle={The Journal of experimental medicine},
  year={2014}
}
Linear ubiquitination is a newly discovered posttranslational modification that is currently restricted to a small number of known protein substrates. The linear ubiquitination assembly complex (LUBAC), consisting of HOIL-1L, HOIP, and Sharpin, has been reported to activate NF-κB-mediated transcription in response to receptor signaling by ligating linear ubiquitin chains to Nemo and Rip1. Despite recent advances, the detailed roles of LUBAC in immune cells remain elusive. We demonstrate a novel… CONTINUE READING
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