The lin-4 microRNA targets the LIN-14 transcription factor to inhibit netrin-mediated axon attraction.

@article{Zou2012TheLM,
  title={The lin-4 microRNA targets the LIN-14 transcription factor to inhibit netrin-mediated axon attraction.},
  author={Yan Zou and Hui Chiu and Doroth{\'e}e Domenger and Chiou-Fen Chuang and Chieh Ting Chang},
  journal={Science signaling},
  year={2012},
  volume={5 228},
  pages={ra43}
}
miR-125 microRNAs, such as lin-4 in Caenorhabditis elegans, were among the first microRNAs discovered, are phylogenetically conserved, and have been implicated in regulating developmental timing. Here, we showed that loss-of-function mutations in lin-4 microRNA increased axon attraction mediated by the netrin homolog UNC-6. The absence of lin-4 microRNA suppressed the axon guidance defects of anterior ventral microtubule (AVM) neurons caused by loss-of-function mutations in slt-1, which encodes… CONTINUE READING
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