The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development.

  title={The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development.},
  author={Linda S Huang and Phoebe Tzou and Paul W. Sternberg},
  journal={Molecular biology of the cell},
  volume={5 4},
During Caenorhabditis elegans vulval development, an inductive signal from the anchor cell stimulates three of the six vulval precursor cells (VPCs) to adopt vulval rather than nonvulval epidermal fates. Genes necessary for this induction include the lin-3 growth factor, the let-23 receptor tyrosine kinase, and let-60 ras. lin-15 is a negative regulator of this inductive pathway. In lin-15 mutant animals, all six VPCs adopt vulval fates, even in the absence of inductive signal. Previous genetic… CONTINUE READING
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