The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells.

@article{Barbu2010TheLC,
  title={The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells.},
  author={Emilia Alina Barbu and Juan Zhang and Reuben P. Siraganian},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 21},
  pages={15761-8}
}
Several studies with mast cells from knock-out mice have suggested that the tyrosine kinase Fyn and its downstream substrate Gab2 may play a role in high affinity IgE receptor (FcepsilonRI)-mediated mast cell activation. To better understand the role of these two molecules and of Syk, we transiently transfected mast cells with small interference RNA (siRNA) targeted to Fyn, Gab2, or Syk to specifically decrease their expression. The siRNA suppression of Gab2 but not Fyn reduced activation of… CONTINUE READING

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740–743 Syk, Fyn, and Gab2 in Mast Cell Signaling 15768 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

Y. Yamashita, N. Charles, +7 authors J. Rivera
J. Immunol • 2007

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