• Medicine
  • Published in
    The Journal of neuroscience…
    2000

The light response of ON bipolar neurons requires G[alpha]o.

@article{Dhingra2000TheLR,
  title={The light response of ON bipolar neurons requires G[alpha]o.},
  author={Anuradha Dhingra and Arkady Lyubarsky and Meisheng Jiang and Edward N Pugh and Lutz Birnbaumer and Peter Sterling and Noga Vardi},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 24},
  pages={
          9053-8
        }
}
ON bipolar neurons in retina detect the glutamate released by rods and cones via metabotropic glutamate receptor 6 (mGluR6), whose cascade is unknown. The trimeric G-protein G(o) might mediate this cascade because it colocalizes with mGluR6. To test this, we studied the retina in mice negative for the alpha subunit of G(o) (Galpha(o)-/-). Retinal layering, key cell types, synaptic structure, and mGluR6 expression were all normal, as was the a-wave of the electroretinogram, which represents the… CONTINUE READING

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