The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3.

@article{Loetscher2001TheLO,
  title={The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3.},
  author={Pius Loetscher and Antonio Pellegrino and J H Gong and Ivan Mattioli and Marcel Loetscher and Giuseppe Bardi and Marco Baggiolini and I Clark-lewis},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 5},
  pages={2986-91}
}
Th1 and Th2 lymphocytes express a different repertoire of chemokine receptors (CCRs). CXCR3, the receptor for I-TAC (interferon-inducible T cell alpha-chemoattractant), Mig (monokine induced by gamma-interferon), and IP10 (interferon-inducible protein 10), is expressed preferentially on Th1 cells, whereas CCR3, the receptor for eotaxin and several other CC chemokines, is characteristic of Th2 cells. While studying responses that are mediated by these two receptors, we found that the agonists… CONTINUE READING
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