The lifetime risks of breast cancer in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations.

@article{Satagopan2001TheLR,
  title={The lifetime risks of breast cancer in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations.},
  author={Jaya M. Satagopan and Kenneth Offit and William D Foulkes and Mark E. Robson and Sholom Wacholder and Christine M. Eng and Stephen Eric Karp and Colin B. Begg},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2001},
  volume={10 5},
  pages={467-73}
}
Several studies using families with multiple occurrences of breast cancer have provided evidence for a very high lifetime penetrance in carriers of BRCA1 or BRCA2 mutations. However, there are reasons to suspect that the estimates of penetrance from studies of cancer families may be inflated. Access to the genotypes of incident cases of breast cancer in three hospitals and from a large series of unaffected survey participants provided the basis for direct estimation of the age-specific relative… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 36 references

Outcome after breast conservation therapy for invasive breast cancer in women with germlineBRCAmutations

M. Robson, D. Levin, +9 authors K. Offit
J. Nat. Canc. Inst., • 1999
View 4 Excerpts
Highly Influenced

Frequency and carrier risk associated with commonBRCA1andBRCA2mutations in Ashkenazi Jewish breast cancer patients

F. H. Fodor, A. Weston, +5 authors C. M. Eng
Am. J. Hum. Genet., • 1998
View 4 Excerpts
Highly Influenced

Population - based estimate of the average age - specific cumulative risk of breast cancer for a defined set of proteintruncating mutations in BRCA 1 and BRCA 2 . Cancer Epidemiol

J. L. Hopper, M. C. Southey, +5 authors D. J. Venter
Genet . Epidemiol . • 2000

Population-based estimate of the average age-specific cumulative risk of breast cancer for a defined set of protein-truncating mutations in BRCA1 and BRCA2. Australian Breast Cancer Family Study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 1999
View 1 Excerpt

Populationbased study of risk of breast cancer in carriers of BRCA2mutation

S. Thorlacius, J. P. Struewing, +6 authors J. E. Eyfjord
Lancet • 1999
View 1 Excerpt

Pregnancy increases the risk of early breast cancer

H. Jernstrom, C. Lerman, +9 authors S. A. Narod
Cancer Epidemiology, Biomarkers & Prevention on October • 1999
View 1 Excerpt

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