The lifetime of hypoxic human tumor cells.

  title={The lifetime of hypoxic human tumor cells.},
  author={Ralph E. Durand and E Sham},
  journal={International journal of radiation oncology, biology, physics},
  volume={42 4},
PURPOSE For hypoxic and anoxic cells in solid tumors to be a therapeutic problem, they must live long enough to be therapeutically relevant, or else be rapidly recruited into the proliferating compartment during therapy. We have, therefore, estimated lifetime and recruitment rate of hypoxic human tumor cells in multicell spheroids in vitro, or in xenografted tumors in SCID mice. MATERIALS AND METHODS Cell turnover was followed by flow cytometry techniques, using antibodies directed at… CONTINUE READING