The life cycle of C-myc: from synthesis to degradation.

  title={The life cycle of C-myc: from synthesis to degradation.},
  author={Rosalie C. Sears},
  journal={Cell cycle},
  volume={3 9},
The c-Myc transcription factor is a potent regulator of cellular proliferation and cell fate decision. Precise regulation of c-Myc protein levels is essential to maintain normal cell function. In order to maintain proper levels of c-Myc, its protein stability is tightly controlled. c-Myc is degraded through the ubiquitin-proteasome pathway. This perspective discusses a sophisticated and complex signaling pathway that controls the life cycle of c-Myc from protein synthesis to ubiquitin-mediated… CONTINUE READING
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