The life and death of gene families

  title={The life and death of gene families},
  author={Jeffery P. Demuth and Matthew W. Hahn},
  • Jeffery P. Demuth, Matthew W. Hahn
  • Published 2009
  • Biology, Medicine
  • BioEssays
  • One of the unique insights provided by the growing number of fully sequenced genomes is the pervasiveness of gene duplication and gene loss. Indeed, several metrics now suggest that rates of gene birth and death per gene are only 10–40% lower than nucleotide substitutions per site, and that per nucleotide, the consequent lineage‐specific expansion and contraction of gene families may play at least as large a role in adaptation as changes in orthologous sequences. While gene family evolution is… CONTINUE READING
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