The life and death of gene families

@article{Demuth2009TheLA,
  title={The life and death of gene families},
  author={Jeffery P. Demuth and Matthew W. Hahn},
  journal={BioEssays},
  year={2009},
  volume={31}
}
  • Jeffery P. Demuth, Matthew W. Hahn
  • Published 2009
  • Biology, Medicine
  • BioEssays
  • One of the unique insights provided by the growing number of fully sequenced genomes is the pervasiveness of gene duplication and gene loss. Indeed, several metrics now suggest that rates of gene birth and death per gene are only 10–40% lower than nucleotide substitutions per site, and that per nucleotide, the consequent lineage‐specific expansion and contraction of gene families may play at least as large a role in adaptation as changes in orthologous sequences. While gene family evolution is… CONTINUE READING
    189 Citations

    Topics from this paper

    Inferring Gene Family Histories in Yeast Identifies Lineage Specific Expansions
    • 6
    • PDF
    Origins, evolution, and phenotypic impact of new genes.
    • 535
    • PDF
    The birth and death of genes
    • 4
    The birth and death of genes
    • 1
    Methods and analysis of genome-scale gene family evolution across multiple species
    • 1
    Robustness of birth-death and gain models for inferring evolutionary events
    • 2
    • PDF
    Molecular evolution and gene function
    • 5
    • PDF

    References

    SHOWING 1-10 OF 117 REFERENCES
    Gene Family Evolution across 12 Drosophila Genomes
    • 325
    • PDF
    The evolutionary demography of duplicate genes
    • M. Lynch, J. Conery
    • Biology, Medicine
    • Journal of Structural and Functional Genomics
    • 2004
    • 292
    • PDF
    Birth and death of orphan genes in Rickettsia.
    • 56
    • PDF
    Modeling gene and genome duplications in eukaryotes.
    • 709
    • PDF
    Gene family evolution and homology: genomics meets phylogenetics.
    • 194