The levels of water-soluble and triton-soluble Aβ are increased in Alzheimer's disease brain.

@article{McDonald2012TheLO,
  title={The levels of water-soluble and triton-soluble Aβ are increased in Alzheimer's disease brain.},
  author={Jessica M McDonald and Nigel J. Cairns and Lisa Taylor-Reinwald and David Holtzman and Dominic M Walsh},
  journal={Brain research},
  year={2012},
  volume={1450},
  pages={138-47}
}
Although plaques composed of the amyloid β-protein (Aβ) are considered a defining feature of Alzheimer's disease (AD), they are also found in cognitively normal individuals and extensive evidence suggests that non-plaque, water-soluble forms of Aβ may play a role in AD pathogenesis. However, the relationship between the levels of water-soluble Aβ and the clinical severity of disease has never been investigated. Here, we present results of a pilot study designed to examine the levels of water… CONTINUE READING

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Amyloid - beta dimers isolated directly from Alzheimer ' s disease brains impair synaptic plasticity and memory

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