The level of residual disease based on mutant NPM1 is an independent prognostic factor for relapse and survival in AML.

@article{Shayegi2013TheLO,
  title={The level of residual disease based on mutant NPM1 is an independent prognostic factor for relapse and survival in AML.},
  author={Nona Shayegi and Michael Kramer and Martin Bornhaeuser and Markus Schaich and Johannes Schetelig and Uwe- Platzbecker and Christoph R{\"o}llig and Caroline Heiderich and Olfert Landt and Gerhard Ehninger and Christian Thiede},
  journal={Blood},
  year={2013},
  volume={122 1},
  pages={83-92}
}
Mutations of the NPM1 gene (NPM1mut) are among the most common genetic alterations in acute myeloid leukemia and are suitable for minimal residual disease detection. We retrospectively investigated the prognostic impact of NPM1mut-based minimal residual disease detection from bone marrow for development of relapse by using a newly developed real-time polymerase chain reaction based on locked nucleic acid-containing primers in 174 patients, 155 of whom were treated within prospective protocols… CONTINUE READING