The level of monocyte turnover predicts disease progression in the macaque model of AIDS.

@article{Hasegawa2009TheLO,
  title={The level of monocyte turnover predicts disease progression in the macaque model of AIDS.},
  author={Atsuhiko Hasegawa and Huining Liu and Binhua Ling and Juan Borda and Xavier Alvarez and Chie Sugimoto and Heather S Vinet-Oliphant and Woong-Ki Kim and Kenneth Williams and Ruy M. Ribeiro and Andrew A Lackner and Ronald S Veazey and Marcelo J. Kuroda},
  journal={Blood},
  year={2009},
  volume={114 14},
  pages={2917-25}
}
It is widely accepted that destruction of CD4(+) T cells and viral load are the primary markers for immunodeficiency in HIV-1-infected humans and in simian immunodeficiency virus (SIV)-infected macaques. However, monocyte/macrophages are also important targets of HIV/SIV infection and a critical link between innate and adaptive immunity. We therefore examined whether changes in cells of the monocyte/macrophage lineage could be linked to the pathogenesis of AIDS in the rhesus macaque model. Here… CONTINUE READING
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