The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature.

@article{Moreaux2005TheLO,
  title={The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature.},
  author={J{\'e}r{\^o}me Moreaux and Friedrich W. Cremer and Thierry R{\'e}me and Marc S Raab and Kar{\'e}ne Mahtouk and Philine Kaukel and V{\'e}ronique Pantesco and John De Vos and Eric Jourdan and Anna Jauch and Eric Legouffe and Marion Moos and Genevi{\`e}ve Fiol and Hartmut Goldschmidt and Jean François Rossi and Dirk Hose and Bernard Klein},
  journal={Blood},
  year={2005},
  volume={106 3},
  pages={1021-30}
}
B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) have been shown to promote multiple myeloma (MM) cell growth. We show that the main site of production for BAFF and APRIL is the bone marrow (BM) environment, and that production is mainly by monocytes and neutrophils. In addition, osteoclasts produce very high levels of APRIL, unlike BM stromal cells. Myeloma cells (MMCs) express TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor… CONTINUE READING
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A new molecular classification of multiple myeloma (MM) using gene expression profiling (GEP) and fluorescence in situ hybridisation as predictor for event free survival (EFS)

  • D Hose, J-F Rossi, C Ittrich
  • Blood
  • 2004

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