The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes.

@article{Cunningham2000TheLO,
  title={The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes.},
  author={Anthony L Cunningham and Shan Li and Jos{\'e} Ignacio Ju{\'a}rez and Grit Lynch and Mohammed Alali and Hassan M. Naif},
  journal={Journal of leukocyte biology},
  year={2000},
  volume={68 3},
  pages={311-7}
}
The outcome of HIV infection in vivo and in vitro depends on the interaction of viral and cellular genotypes. Analysis of infection of blood monocyte-derived macrophages by primary HIV strains shows that approximately one-third of 32 isolates was consistently high-replicating, one-third was consistently low-replicating, and one-third was dependent on the donor of the macrophages (i.e., variable). HIV isolates from patients with AIDS showed enhanced replication within macrophages and predominant… CONTINUE READING