The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL.

@article{Khalil2009TheLA,
  title={The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL.},
  author={Maroun Bou Khalil and M. S. Kalyana Sundaram and Hong-Yu Zhang and Philip H Links and Jennifer F. Raven and Boripont Manmontri and Meltem Sariahmetoglu and Khai A Tran and Karen Reue and David N. Brindley and Zemin Yao},
  journal={Journal of lipid research},
  year={2009},
  volume={50 1},
  pages={
          47-58
        }
}
Phosphatidate phosphatase-1 (PAP-1) converts phosphatidate to diacylglycerol and plays a key role in the biosynthesis of phospholipids and triacylglycerol (TAG). PAP-1 activity is encoded by members of the lipin family, including lipin-1 (1alpha and 1beta), -2, and -3. We determined the effect of lipin-1 expression on the assembly and secretion of very low density lipoproteins (VLDL) using McA-RH7777 cells. Expression of lipin-1alpha or -1beta increased the synthesis and secretion of [(3)H… CONTINUE READING

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