The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans.

@article{Islam2005TheLB,
  title={The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans.},
  author={Sabina A. Islam and Seddon Y. Thomas and Christoph Hess and Benjamin D Medoff and Terry K. Means and Christian Brander and Craig M. Lilly and Andrew M Tager and Andrew D Luster},
  journal={Blood},
  year={2005},
  volume={107 2},
  pages={
          444-53
        }
}
We have recently shown that the leukotriene B(4) (LTB(4))-BLT1 pathway is important in early effector T-cell recruitment in mouse models of inflammation. Here we characterize the phenotype and function of human peripheral blood BLT1(+) T cells in health and illustrate their involvement in asthma and acute infection. In healthy individuals, BLT1(+) T cells are a rare peripheral blood T-cell population enriched for the activation markers CD38 and HLA-DR. Compared with BLT1(-) T cells, a larger… CONTINUE READING

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