The leukemic stem cell niche: current concepts and therapeutic opportunities.

  title={The leukemic stem cell niche: current concepts and therapeutic opportunities.},
  author={Steven W Lane and David T Scadden and Dwight Gary Gilliland},
  volume={114 6},
The genetic events that contribute to the pathogenesis of acute myeloid leukemia are among the best characterized of all human malignancies. However, with notable exceptions such as acute promyelocytic leukemia, significant improvements in outcome based on these insights have not been forthcoming. Acute myeloid leukemia is a paradigm of cancer stem (or leukemia initiating) cells with hierarchy analogous to that seen in hematopoiesis. Normal hematopoiesis requires complex bidirectional… CONTINUE READING
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