The leucine zipper of NRL interacts with the CRX homeodomain. A possible mechanism of transcriptional synergy in rhodopsin regulation.

@article{Mitton2000TheLZ,
  title={The leucine zipper of NRL interacts with the CRX homeodomain. A possible mechanism of transcriptional synergy in rhodopsin regulation.},
  author={Kenneth P. Mitton and Prabodh K. Swain and S Chen and Siqun Xu and Don J Zack and Anand Swaroop},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 38},
  pages={29794-9}
}
Photoreceptor-specific expression of rhodopsin is mediated by multiple cis-acting elements in the proximal promoter region. NRL (neural retina leucine zipper) and CRX (cone rod homeobox) proteins bind to the adjacent NRE and Ret-4 sites, respectively, within this region. Although NRL and CRX are each individually able to induce rhodopsin promoter activity, when expressed together they exhibit transcriptional synergy in rhodopsin promoter activation. Using the yeast two-hybrid method and… CONTINUE READING
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