The leucine twenty homeobox (LEUTX) gene, which lacks a histone acetyltransferase domain, is fused to KAT6A in therapy‐related acute myeloid leukemia with t(8;19)(p11;q13)

  title={The leucine twenty homeobox (LEUTX) gene, which lacks a histone acetyltransferase domain, is fused to KAT6A in therapy‐related acute myeloid leukemia with t(8;19)(p11;q13)},
  author={Yoshiaki Chinen and Tomohiko Taki and Yasuhiko Tsutsumi and Satoru Kobayashi and Yosuke Matsumoto and Natsumi Sakamoto and Junya Kuroda and Shigeo Horiike and Kazuhiro Nishida and Hirofumi Ohno and Naokuni Uike and Masafumi Taniwaki},
The monocytic leukemia zinc finger protein KAT6A (formerly MOZ) gene is recurrently rearranged by chromosomal translocations in acute myeloid leukemia (AML). KAT6A is known to be fused to several genes, all of which have histone acetyltransferase (HAT) activity and interact with a number of transcription factors as a transcriptional coactivator. The present study shows that the leucine twenty homeobox (LEUTX) gene on 19q13 is fused to the KAT6A gene on 8p11 in a therapy‐related AML with t(8;19… 
Therapy-related Myeloid Leukemia With the Translocation t(8;19)(p11;q13) Leading to a KAT6A-LEUTX Fusion Gene
The present case is the second therapy-related AML, and the third AML overall, in which both a t(8;19)(p11;q13) and its molecular result, a KAT6A-LEUTX fusion gene, are described, which deregulates transcription and induces leukemogenesis.
The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation
Using a human embryonic stem cell overexpression model, it is shown that the complete homeodomain isoform is functional and sufficient to activate the transcription of a large proportion of the genes that are upregulated in human embryo genome activation (EGA).
The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival*
It is reported that endogenous BRPF3 preferentially forms a tetrameric complex with HBO1 and two other subunits but not with related acetyltransferases such as MOZ, MORF, TIP60, and MOF (also known as KAT6A, KAT5, and KAT8, respectively).
Functional proteomics of the epigenetic regulators ASXL1, ASXL2 and ASXL3: a convergence of proteomics and epigenetics for translational medicine
  • M. Katoh
  • Biology
    Expert review of proteomics
  • 2015
The cell context-dependent epigenetic code of ASXLs should be deciphered to develop therapeutics for human diseases, with emphasis on mutation spectra, the ASXM2 domain and the plant homeodomain (PHD) finger.
A Review on Important Histone Acetyltransferase (HAT) Enzymes as Targets for Cancer Therapy
The important roles of HATs in different human malignancies are reviewed to indicate that HAT might be an important target for effective cancer treatments, and hence there would be a need for further studies and designing of therapeutic drugs on this basis.
Transcriptome analysis identifies key regulators and networks in Acute myeloid leukemia
Regulation of the HOXA gene family and its regulation played an important role in the development of AML, and the results showed that his-mir-335 was a critical regulatory of homeobox A gene family.
t(8;16)(p11;p13) KAT6A/CREBBP
Phenotype/cell stem origin AML with t(8;16) may arise from an early stem cell with myeloid and monoblastic differentiation potential and the genes implicated are found to be involved in variant translocations associated with M5/M4 AML.
The key roles of the lysine acetyltransferases KAT6A and KAT6B in physiology and pathology.
Rapidly progressing acute myeloid leukemia with KAT6A‐LEUTX fusion in a newborn
A case of rapidly progressing cAML with a very rare KAT6A-LEUTX fusion resulting from t(8;19)(p11;q13) resulting from a severe right ventricle kinetic disorder of a 16-day-old female newborn who died the same day due to a rapidly developing irreversible cardiac failure.


Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11) (p21;q23).
A novel fusion partner of MLL (FAB M5b) is identified in a patient who developed t-AML 9 years after treatment for acute lymphoblastic leukemia (ALL).
MOZ is fused to p300 in an acute monocytic leukemia with t(8;22)
A novel reciprocal translocation involving two acetyltransferases, MOZ and p300, resulting in an abnormal transcriptional co‐activator that could play a critical role in leukemogenesis is defined.
Acute mixed lineage leukemia with an inv(8)(p11q13) resulting in fusion of the genes for MOZ and TIF2.
The MOZ-TIF2 fusion is one of a new family of chromosomal rearrangements that associate HAT activity, transcriptional coactivation, and acute leukemia.
Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t(12;13)(p13;q12).
R reverse transcription-PCR analysis showed that CDX2 mRNA, but not ETV6-CDX2 RNA, was strongly expressed in 1 of 10 patients with chronic myeloid leukemia in transformation, suggesting that deregulation of this gene may be more widespread in leukemia.
The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB–binding protein
It is suggested that MOZ may represent a chromatin-associated acetyltransferase, and the possibility that a dominant MOZ–CBP fusion protein could mediate leukaemogenesis via aberrant chromatin acetylation is raised.
Identification of the novel AML1 fusion partner gene, LAF4, a fusion partner of MLL, in childhood T-cell acute lymphoblastic leukemia with t(2;21)(q11;q22) by bubble PCR method for cDNA
It is identified that the LAF4 gene on 2q11.2–12 was fused to the AML1 gene on 21q22 in a pediatric patient having T-cell acute lymphoblastic leukemia (T-ALL) with t(2;21)(q11;q22) using the bubble PCR method for cDNA.
NCOA3, a new fusion partner for MOZ/MYST3 in M5 acute myeloid leukemia
A new type of translocation, t(8;20)(p11;q13), which occurs in an M5-AML and fuses MYST3 to NCOA3 is reported here and is suspected or predicted on the basis of homology relations.
Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells
The role of the interaction between MOZ and MLL in CD34+ cells is unveiled, in which both proteins have a critical role in hematopoietic cell-fate decision, suggesting a new molecular mechanism by which MOZ or MLL deregulation leads to leukemogenesis.
Identification and characterization of ASXL3 gene in silico.
The ASXL3 gene, a novel human homolog of Drosophila asx, is identified by using bioinformatics and was a predicted cancer-associated gene, just like ASXL1 and ASXL2.
Rearrangement of the MOZ gene in pediatric therapy‐related myelodysplastic syndrome with a novel chromosomal translocation t(2;8)(p23;p11)
It is believed that MOZ, fused to an unidentified partner gene at 2p23, may have caused an alteration in histone acetylation, resulting in the development of tMDS in this patient.