The leucine twenty homeobox (LEUTX) gene, which lacks a histone acetyltransferase domain, is fused to KAT6A in therapy‐related acute myeloid leukemia with t(8;19)(p11;q13)

@article{Chinen2014TheLT,
  title={The leucine twenty homeobox (LEUTX) gene, which lacks a histone acetyltransferase domain, is fused to KAT6A in therapy‐related acute myeloid leukemia with t(8;19)(p11;q13)},
  author={Yoshiaki Chinen and Tomohiko Taki and Yasuhiko Tsutsumi and Satoru Kobayashi and Yosuke Matsumoto and Natsumi Sakamoto and Junya Kuroda and Shigeo Horiike and Kazuhiro Nishida and Hirofumi Ohno and Naokuni Uike and Masafumi Taniwaki},
  journal={Genes},
  year={2014},
  volume={53}
}
The monocytic leukemia zinc finger protein KAT6A (formerly MOZ) gene is recurrently rearranged by chromosomal translocations in acute myeloid leukemia (AML). KAT6A is known to be fused to several genes, all of which have histone acetyltransferase (HAT) activity and interact with a number of transcription factors as a transcriptional coactivator. The present study shows that the leucine twenty homeobox (LEUTX) gene on 19q13 is fused to the KAT6A gene on 8p11 in a therapy‐related AML with t(8;19… 
Therapy-related Myeloid Leukemia With the Translocation t(8;19)(p11;q13) Leading to a KAT6A-LEUTX Fusion Gene
TLDR
The present case is the second therapy-related AML, and the third AML overall, in which both a t(8;19)(p11;q13) and its molecular result, a KAT6A-LEUTX fusion gene, are described, which deregulates transcription and induces leukemogenesis.
The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation
TLDR
Using a human embryonic stem cell overexpression model, it is shown that the complete homeodomain isoform is functional and sufficient to activate the transcription of a large proportion of the genes that are upregulated in human embryo genome activation (EGA).
The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival*
TLDR
It is reported that endogenous BRPF3 preferentially forms a tetrameric complex with HBO1 and two other subunits but not with related acetyltransferases such as MOZ, MORF, TIP60, and MOF (also known as KAT6A, KAT5, and KAT8, respectively).
Functional proteomics of the epigenetic regulators ASXL1, ASXL2 and ASXL3: a convergence of proteomics and epigenetics for translational medicine
  • M. Katoh
  • Biology
    Expert review of proteomics
  • 2015
TLDR
The cell context-dependent epigenetic code of ASXLs should be deciphered to develop therapeutics for human diseases, with emphasis on mutation spectra, the ASXM2 domain and the plant homeodomain (PHD) finger.
A Review on Important Histone Acetyltransferase (HAT) Enzymes as Targets for Cancer Therapy
TLDR
The important roles of HATs in different human malignancies are reviewed to indicate that HAT might be an important target for effective cancer treatments, and hence there would be a need for further studies and designing of therapeutic drugs on this basis.
Transcriptome analysis identifies key regulators and networks in Acute myeloid leukemia
TLDR
Regulation of the HOXA gene family and its regulation played an important role in the development of AML, and the results showed that his-mir-335 was a critical regulatory of homeobox A gene family.
t(8;16)(p11;p13) KAT6A/CREBBP
TLDR
Phenotype/cell stem origin AML with t(8;16) may arise from an early stem cell with myeloid and monoblastic differentiation potential and the genes implicated are found to be involved in variant translocations associated with M5/M4 AML.
The key roles of the lysine acetyltransferases KAT6A and KAT6B in physiology and pathology.
Rapidly progressing acute myeloid leukemia with KAT6A‐LEUTX fusion in a newborn
TLDR
A case of rapidly progressing cAML with a very rare KAT6A-LEUTX fusion resulting from t(8;19)(p11;q13) resulting from a severe right ventricle kinetic disorder of a 16-day-old female newborn who died the same day due to a rapidly developing irreversible cardiac failure.
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