The leucine-rich repeat protein PRELP binds fibroblast cell-surface proteoglycans and enhances focal adhesion formation.

@article{Bengtsson2016TheLR,
  title={The leucine-rich repeat protein PRELP binds fibroblast cell-surface proteoglycans and enhances focal adhesion formation.},
  author={Eva Lena Bengtsson and Karin Lindblom and Viveka Tillgren and Anders Aspberg},
  journal={The Biochemical journal},
  year={2016},
  volume={473 9},
  pages={
          1153-64
        }
}
PRELP (proline/arginine-rich end leucine-rich repeat protein) is a member of the leucine-rich repeat (LRR) family of extracellular matrix proteins in connective tissue. In contrast with other members of the family, the N-terminal domain of PRELP has a high content of proline and positively charged amino acids. This domain has previously been shown to bind chondrocytes and to inhibit osteoclast differentiation. In the present study, we show that PRELP mediates cell adhesion by binding to cell… CONTINUE READING
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