The lethal myospheroid gene of Drosophila encodes a membrane protein homologous to vertebrate integrin beta subunits.

@article{MacKrell1988TheLM,
  title={The lethal myospheroid gene of Drosophila encodes a membrane protein homologous to vertebrate integrin beta subunits.},
  author={A J MacKrell and Bruce Mitchell Blumberg and Susan R. Haynes and John H. Fessler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 8},
  pages={2633-7}
}
A mutant of Drosophila melanogaster carrying the lethal(1) myospheroid mutation [l(1)mys] has a defective musculature and a phenotype that suggests a defect of basement membranes. The genomic region that is interrupted by an insertion in a mutant carrying l(1)mys was used to isolate cDNA clones, and their sequences are presented here. The cDNA sequence predicts a cysteine-rich integral membrane protein that displays 45% sequence identity to chicken integrin and the human fibronectin receptor… CONTINUE READING
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