The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.

@article{Yu2003TheLE,
  title={The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.},
  author={Chunrong Yu and Mohamed Rahmani and Yun Dai and Daniel Conrad and Geoffrey W. Krystal and Paul C Dent and Steven Grant},
  journal={Cancer research},
  year={2003},
  volume={63 8},
  pages={1822-33}
}
The impact of disruption of the PI3K (phosphatidylinositol 3-kinase) pathway on the response of human leukemia cells to pharmacological cyclin-dependent kinase (CDK) inhibitors has been examined. Exposure of U937 monocytic leukemia cells to minimally toxic concentrations of flavopiridol (FP), roscovitine, or CGP74514A for 3 h in conjunction with the PI3K inhibitor LY294002 (abbreviated LY in the article) resulted in a marked decrease in Akt phosphorylation. Coexposure of cells to LY and CDK… CONTINUE READING
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Loss of the N-terminal phosphorylation loop domain is required to protect human leukemia cells (U937) overexpressing Bcl-2 from flavopiridol-induced lethality

  • R. Decker, S. Wang, S. Grant
  • Cancer Biol. Ther.,
  • 2002
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