The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable.

@article{Lawrence2021TheLO,
  title={The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable.},
  author={Jack M Lawrence and Gideon Meyerowitz-Katz and James A. J. Heathers and Nicholas J L Brown and Kyle Sheldrick},
  journal={Nature medicine},
  year={2021}
}
To the Editor — The global demand for prophylactic and treatment options for COVID-19 has in turn created a demand for both randomized clinical trials, and the synthesis of those trials into meta-analyses by systematic review. This process has been fraught, and has demonstrated the inherent risks in current approaches and accepted standards of quantitative evidence synthesis when dealing with high volumes of recent, often unpublished trial data of variable quality. Research into the use of… 
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