# The length of time required for a selectively neutral mutant to reach fixation through random frequency drift in a finite population.

@article{Kimura1970TheLO, title={The length of time required for a selectively neutral mutant to reach fixation through random frequency drift in a finite population.}, author={M Kimura}, journal={Genetical research}, year={1970}, volume={15 1}, pages={ 131-3 } }

A general theory concerning the average number of generations until a mutant gene becomes fixed (established) in a finite population was developed by Kimura & Ohta (1969a) based on the diffusion models. For the special case of selectively neutral mutants, the problem was simplified and it was shown by them that the average length of time until fixation (excluding the cases of eventual loss) is approximately 4:Ne generations, where Ne is the 'variance' effective number of the population (cf…

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