The leguminous lectin of Lonchocarpus araripensis promotes antinociception via mechanisms that include neuronal inhibition of Na+ currents

@article{Amorim2016TheLL,
  title={The leguminous lectin of Lonchocarpus araripensis promotes antinociception via mechanisms that include neuronal inhibition of Na+ currents},
  author={Renata Morais Ferreira Amorim and Alana de Freitas Pires and T Santos-Nascimento and Benildo Sousa Cavada and Kyria Santiago Nascimento and Jo{\~a}o Batista Cajazeiras and Jos{\'e} Henrique Leal-Cardoso and M{\'a}rio Rog{\'e}rio Lima Mota and Ana Maria Sampaio Assreuy},
  journal={Inflammation Research},
  year={2016},
  volume={65},
  pages={701-708}
}
Objective and designSodium channels are highly expressed in nociceptive sensory neurons during hypernociceptive conditions. Based on the presence of a glycosidic portion in the sodium channel β subunit associated to the antinociceptive effect of leguminous lectins via lectin domain, this study investigated the antinociceptive activity of the lectin isolated from Lonchocarpus araripensis seeds (LAL) in mice behavioral models and in NaV current in the nociceptor of rat dorsal root ganglion (DRG… 
Antinociceptive effect of Lonchocarpus araripensis lectin: activation of l-arginine/NO/cGMP/K+ATP signaling pathway
TLDR
LAL increased (95%) nNOS gene expression in mice paw tissues, but not its immunoexpression in the dorsal root ganglia, and LAL effect was reversed by nifedipine, niflumic acid, and glibenclamide, but was unaltered by aminoguanidine.
The Antinociceptive Effect of Lonchocarpus Araripensis Lectin is Mediated by Endocannabinoid Receptors
TLDR
The involvement of endocannabinoid receptors in the antinociceptive activity of Lonchocarpus araripensis lectin was investigated in the model of carragenan-induced hypernociception and reversed the inhibitory effect of LAL.
Dalbergieae lectins: A review of lectins from species of a primitive Papilionoideae (leguminous) tribe.
Structural studies and nociceptive activity of a native lectin from Platypodium elegans seeds (nPELa).

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