The leguminous lectin of Lonchocarpus araripensis promotes antinociception via mechanisms that include neuronal inhibition of Na+ currents

  title={The leguminous lectin of Lonchocarpus araripensis promotes antinociception via mechanisms that include neuronal inhibition of Na+ currents},
  author={Renata Morais Ferreira Amorim and Alana de Freitas Pires and T Santos-Nascimento and Benildo Sousa Cavada and Kyria Santiago Nascimento and Jo{\~a}o Batista Cajazeiras and Jos{\'e} Henrique Leal-Cardoso and M{\'a}rio Rog{\'e}rio Lima Mota and Ana Maria Sampaio Assreuy},
  journal={Inflammation Research},
Objective and designSodium channels are highly expressed in nociceptive sensory neurons during hypernociceptive conditions. Based on the presence of a glycosidic portion in the sodium channel β subunit associated to the antinociceptive effect of leguminous lectins via lectin domain, this study investigated the antinociceptive activity of the lectin isolated from Lonchocarpus araripensis seeds (LAL) in mice behavioral models and in NaV current in the nociceptor of rat dorsal root ganglion (DRG… 
Antinociceptive effect of Lonchocarpus araripensis lectin: activation of l-arginine/NO/cGMP/K+ATP signaling pathway
LAL increased (95%) nNOS gene expression in mice paw tissues, but not its immunoexpression in the dorsal root ganglia, and LAL effect was reversed by nifedipine, niflumic acid, and glibenclamide, but was unaltered by aminoguanidine.
The Antinociceptive Effect of Lonchocarpus Araripensis Lectin is Mediated by Endocannabinoid Receptors
The involvement of endocannabinoid receptors in the antinociceptive activity of Lonchocarpus araripensis lectin was investigated in the model of carragenan-induced hypernociception and reversed the inhibitory effect of LAL.
Dalbergieae lectins: A review of lectins from species of a primitive Papilionoideae (leguminous) tribe.
Structural studies and nociceptive activity of a native lectin from Platypodium elegans seeds (nPELa).


Opioid‐like antinociceptive effects of oral administration of a lectin purified from the seeds of Canavalia brasiliensis
When administered orally to Swiss mice, the ConBr lectin displayed antinociceptive activity, both peripheral and central, mediated by the opioid system and involving δ‐and κ‐receptors and the lectin domain.
A novel N-acetyl-glucosamine lectin of Lonchocarpus araripensis attenuates acute cellular inflammation in mice
The novel N-acetyl-d-glucosamine-binding lectin isolated from L. araripensis seeds presents anti-inflammatory effect involving the lectin domain and the inhibition of 5-HT, BK, PGE2, NO, TNF-α and leukocyte rolling and adhesion.
Antinociceptive activity and toxicology of the lectin from Canavalia boliviana seeds in mice
Results show that CboL presents antinociceptive effects of both central and peripheral origin, involving the participation of the opioid system via lectin domain.
Lonchocarpus sericeus lectin decreases leukocyte migration and mechanical hypernociception by inhibiting cytokine and chemokines production.
Leguminous lectins as tools for studying the role of sugar residues in leukocyte recruitment.
An important role is suggested for N-acetylglucosamine residue as the major ligand for selectins on rat neutrophil membranes in the face of peritonitis and paw oedema models induced by carrageenin in rats.
Homologous Canavalia Lectins Elicit Different Patterns of Antinociceptive Responses
The antinociceptive activity of the structural homologous lectins was differentiated by potency, efficacy and mechanisms.
In vivo evidence for a role of protein kinase C in peripheral nociceptive processing
It is demonstrated that PKC activation at peripheral tissues leads to the development of spontaneous nociceptive response, thermal hyperalgesia and mechanical allodynia, and in vivo evidence that peripheral PKCactivation is essential for the full establishment of the nocICEptive response induced by two different inflammatory stimuli.
Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C.
The findings indicate that different second messenger pathways underlie acute and prolonged inflammatory pain, which may have a role in chronic inflammatory pain.
Carvacrol decreases neuronal excitability by inhibition of voltage-gated sodium channels.
It has been demonstrated that 1 blocks neuronal excitability by a direct inhibition of the voltage-gated sodium current, which suggests that this compound acts as a local anesthetic.