The legacy of domestication: accumulation of deleterious mutations in the dog genome.

@article{Cruz2008TheLO,
  title={The legacy of domestication: accumulation of deleterious mutations in the dog genome.},
  author={Fernando Cruz and Carles Vil{\`a} and Matthew T Webster},
  journal={Molecular biology and evolution},
  year={2008},
  volume={25 11},
  pages={
          2331-6
        }
}
Dogs exhibit more phenotypic variation than any other mammal and are affected by a wide variety of genetic diseases. However, the origin and genetic basis of this variation is still poorly understood. We examined the effect of domestication on the dog genome by comparison with its wild ancestor, the gray wolf. We compared variation in dog and wolf genes using whole-genome single nucleotide polymorphism (SNP) data. The d(N)/d(S) ratio (omega) was around 50% greater for SNPs found in dogs than in… CONTINUE READING

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