The lectin pathway of complement activation contributes to protection from West Nile virus infection.

@article{Fuchs2011TheLP,
  title={The lectin pathway of complement activation contributes to protection from West Nile virus infection.},
  author={Anja G. Fuchs and Amelia K Pinto and Wilhelm J Schwaeble and Michael S Diamond},
  journal={Virology},
  year={2011},
  volume={412 1},
  pages={101-9}
}
The function of the lectin pathway of complement activation in vivo against West Nile virus (WNV) or many other pathogenic viruses has not been defined. Mice deficient in lectin pathway recognition molecules (mannose binding lectin-A (MBL-A) and mannose binding lectin-C (MBL-C)) or the effector enzyme mannan-binding lectin-associated serine protease-2 (MASP-2), were more vulnerable to WNV infection than wild type mice. Compared with studies of mice deficient in factors of the classical or… CONTINUE READING

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Scandinavian journal of gastroenterology • 2000
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