The leader proteinase of foot-and-mouth disease virus: structure-function relationships in a proteolytic virulence factor.

@article{Steinberger2014TheLP,
  title={The leader proteinase of foot-and-mouth disease virus: structure-function relationships in a proteolytic virulence factor.},
  author={Jutta Steinberger and Tim Skern},
  journal={Biological chemistry},
  year={2014},
  volume={395 10},
  pages={1179-85}
}
The leader proteinase (Lpro) of the foot-and-mouth disease virus inhibits the host innate immune response by at least three different mechanisms. The most well-characterised of these is the prevention of the synthesis of cytokines such as interferons immediately after infection, brought about by specific proteolytic cleavage of the eukaryotic initiation factor 4G. This prevents the recruitment of capped cellular mRNA; however, the viral RNA can be translated under these conditions. The two… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…