The leader peptide of Theiler's murine encephalomyelitis virus is a zinc-binding protein.

@article{Chen1995TheLP,
  title={The leader peptide of Theiler's murine encephalomyelitis virus is a zinc-binding protein.},
  author={Homer H. Chen and W P Kong and Raymond P. Roos},
  journal={Journal of virology},
  year={1995},
  volume={69 12},
  pages={8076-8}
}
The leader (L) peptide is located in the amino-terminal part of the polyprotein of members of the Cardiovirus (which includes Theiler's murine encephalomyelitis virus) and Aphthovirus genera of picornaviruses. Although the function of L is unknown, strain DA of Theiler's murine encephalomyelitis virus with a mutation of L produces a cell-specific restricted infection. We now report that the DA L peptide is a metalloprotein and that zinc binds to a Cys-His motif that is conserved among… CONTINUE READING

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Analysis of the poliovirus 2BC proteins, abstr. P12-5

T. Pfister, A. Molla, E. Wimmer
1995

Involvement of cardiovirus leader in host cell-restricted virus expression.

Proceedings of the National Academy of Sciences of the United States of America • 1994

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