The lateral septum as a regulator of hippocampal theta oscillations and defensive behavior in rats.

@article{Chee2015TheLS,
  title={The lateral septum as a regulator of hippocampal theta oscillations and defensive behavior in rats.},
  author={San-San Amy Chee and Janet L. Menard and Hans C Dringenberg},
  journal={Journal of neurophysiology},
  year={2015},
  volume={113 6},
  pages={
          1831-41
        }
}
Hippocampal theta oscillations are linked to various processes, including locomotion, learning and memory, and defense and affect. The lateral septum (LS) has been implicated in the generation of the hippocampal theta rhythm, but its precise role in this process is not well understood. Here, we investigated the effects of direct pharmacological inhibition or disinhibition of the dorsal LS (dLS) on the frequency of hippocampal theta activity elicited by stimulation of the reticular formation in… 
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A role for the LS is suggested in transmitting spatial and contextual information, in concert with locomotor information, to downstream areas, such as the VTA, where value weighting may take place.
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Disturbances of learning and memory are related to the impaired expression of rhythmic activity and phase synchronization in the hippocampus, entorhinal cortex, and other cortical areas. Several
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TLDR
The results suggest that theta frequency does not relate to levels of anxiety‐like behaviours in the EPM in male and female rats, challenging the predictive validity of hippocampal theta activity as an index of anxiety in rodents.
Lateral septum as a nexus for mood, motivation, and movement
TLDR
It is suggested that the lateral septum incorporates movement into the evaluation of environmental context with respect to motivation, anxiety, and reward to output an 'integrated movement value signal' in the LS to inform task-relevant decisions.
Involvement of Serotonergic and Relaxin-3 Neuropeptide Systems in the Expression of Anxiety-like Behavior
Anxiety-related defensive behavior is controlled by a distributed network of brain regions and interconnected neural circuits. The dorsal raphe nucleus (DR), which contains the majority of
Involvement of the dorsal hippocampus in expression and extinction of cocaine‐induced conditioned place preference
TLDR
The effects of hippocampal inactivation on expression of cocaine‐induced conditioned place preference (CPP) after initial acquisition or extinction of CPP in C57BL/6 mice differed depending on the spatial configuration during Acquisition or extinction, suggesting that the dorsal hippocampus may differentially modulate drug seeking during retrieval and extinction ofCPP.
Differential and complementary roles of medial and lateral septum in the orchestration of limbic oscillations and signal integration
  • M. Tsanov
  • Biology, Medicine
    The European journal of neuroscience
  • 2018
TLDR
The hypothesis that the medial septum mediates ascending septo‐hippocampal theta propagation and processes a descending hippocampo‐septal and sePTo‐hypothalamic reinforcement signal that mediates navigation during motivated behaviour is explored.
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