The lateral prefrontal cortex mediates the hyperalgesic effects of negative cognitions in chronic pain patients.

@article{Loggia2015TheLP,
  title={The lateral prefrontal cortex mediates the hyperalgesic effects of negative cognitions in chronic pain patients.},
  author={Marco L Loggia and Chantal Berna and Jieun Kim and Christine M Cahalan and Marc-Olivier Martel and Randy L. Gollub and Ajay D. Wasan and Vitaly Napadow and Robert F R Edwards},
  journal={The journal of pain : official journal of the American Pain Society},
  year={2015},
  volume={16 8},
  pages={692-9}
}
UNLABELLED Although high levels of negative affect and cognitions have been associated with greater pain sensitivity in chronic pain conditions, the neural mechanisms mediating the hyperalgesic effect of psychological factors in patients with pain disorders are largely unknown. In this cross-sectional study, we hypothesized that 1) catastrophizing modulates brain responses to pain anticipation and 2) anticipatory brain activity mediates the hyperalgesic effect of different levels of… CONTINUE READING
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