The latent membrane protein 2 gene of Epstein-Barr virus is important for efficient B cell immortalization.

@article{Brielmeier1996TheLM,
  title={The latent membrane protein 2 gene of Epstein-Barr virus is important for efficient B cell immortalization.},
  author={Markus Brielmeier and Josef Mautner and Gerhard Laux and Wolfgang Hammerschmidt},
  journal={The Journal of general virology},
  year={1996},
  volume={77 ( Pt 11)},
  pages={2807-18}
}
The viral latent membrane proteins 2 (LMP2) of Epstein-Barr virus (EBV) were analysed genetically to evaluate their role in B cell immortalization. LMP2 is transcribed as two differently spliced mRNAs which code for the LMP2A and -B proteins, also called terminal protein-1 and -2. LMP2A and -B are found in latently infected, growth-transformed B lymphocytes in vitro, in different human tumours, and in latently infected B cells in vivo. Two different approaches were used to generate EBV mutants… CONTINUE READING

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