The late flowering phenotype of fwa mutants is caused by gain-of-function epigenetic alleles of a homeodomain gene.

@article{Soppe2000TheLF,
  title={The late flowering phenotype of fwa mutants is caused by gain-of-function epigenetic alleles of a homeodomain gene.},
  author={Wim J. J. Soppe and Steven E. Jacobsen and Carlos Alonso-Blanco and James P. Jackson and Tetsuji Kakutani and Maarten Koornneef and Anton J. M. Peeters},
  journal={Molecular cell},
  year={2000},
  volume={6 4},
  pages={791-802}
}
The transition to flowering in Arabidopsis thaliana is delayed in fwa mutant plants. FWA was identified by loss-of-function mutations in normally flowering revertants of the fwa mutant, and it encodes a homeodomain-containing transcription factor. The DNA sequence of wild-type and fwa mutant alleles was identical in the genomic region of FWA. Furthermore, the FWA gene is ectopically expressed in fwa mutants and silenced in mature wild-type plants. This silencing is associated with extensive… CONTINUE READING
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, and Koornneef , silencing in plants

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