The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway.

@article{Malpel2007TheL5,
  title={The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway.},
  author={S{\'e}bastien Malpel and S. P. Angelin Claret and Matthieu Sanial and Amira Brigui and Tristan Piolot and Laurent Daviet and S{\'e}verine Martin-Lanner{\'e}e and Anne Plessis},
  journal={Developmental biology},
  year={2007},
  volume={303 1},
  pages={121-33}
}
The Hedgehog (HH) signaling pathway is crucial for the development of many organisms and its inappropriate activation is involved in numerous cancers. HH signal controls the traffic and activity of the seven-pass transmembrane protein Smoothened (SMO), leading to the transcriptional regulation of HH-responsive genes. In Drosophila, the intracellular transduction events following SMO activation depend on cytoplasmic multimeric complexes that include the Fused (FU) protein kinase. Here we show… CONTINUE READING