The larval specific lymphatic filarial ALT-2: induction of protection using protein or DNA vaccination.

@article{Ramachandran2004TheLS,
  title={The larval specific lymphatic filarial ALT-2: induction of protection using protein or DNA vaccination.},
  author={Sabarinathan Ramachandran and Mishra Pankaj Kumar and Reddy Maryada Venkata Rami and Harinath Basker Chinnaiah and Thomas B Nutman and Perumal Kaliraj and James K. McCarthy},
  journal={Microbiology and immunology},
  year={2004},
  volume={48 12},
  pages={945-55}
}
Genes from the infective stage of lymphatic filarial parasites expressed at the time of host invasion have been identified as potential vaccine candidates. By screening an L3 cDNA library with sera from uninfected longstanding residents of an area endemic for onchocerciasis, so-called "endemic normals" (EN), we have cloned and characterized one such gene termed the abundant larval transcript two (ALT-2). The stage specificity of ALT-2 gene transcription and protein synthesis was confirmed by… CONTINUE READING

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