The largest variant of platelet glycoprotein Ib alpha has four tandem repeats of 13 amino acids in the macroglycopeptide region and a genetic linkage with methionine145.

@article{Ishida1995TheLV,
  title={The largest variant of platelet glycoprotein Ib alpha has four tandem repeats of 13 amino acids in the macroglycopeptide region and a genetic linkage with methionine145.},
  author={Fumihiro Ishida and Kenichi Furihata and Kenji Ishida and Jib Yan and Kiyoshi Kitano and Kendo Kiyosawa and Shigeyuki Furuta},
  journal={Blood},
  year={1995},
  volume={86 4},
  pages={
          1357-60
        }
}
Platelet membrane glycoprotein Ib alpha (GPIb alpha) bears the human platelet alloantigen (HPA)-2 and molecular weight (MW) polymorphisms on sodium dodecyl sulfate-polyacrylamide gels. HPA-2 arises from a threonine/methionine dimorphism at residue 145 of the GPIb alpha sequence, whereas different numbers of tandem repeats of a 39-bp sequence encoding 13-amino acids corresponding to a region between serine399 and threonine411 of the GPIb alpha account for the latter. To identify the genetic… CONTINUE READING

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