The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions.

  title={The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions.},
  author={Alagarsamy Srinivasan and Keith W. C. Peden and James M. Pipas},
  journal={Journal of virology},
  volume={63 12},
The large tumor antigen (T antigen) of simian virus 40 is necessary and sufficient for the neoplastic transformation of a number of established cell lines. Mutational analysis has revealed that a biochemical activity residing within the amino-terminal 121 amino acids of T antigen is sufficient to induce the transformation of some cell lines, such as C3H10T1/2. The same domain of the molecule also encodes the transactivation function of T antigen and the ability to complex with the… CONTINUE READING

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Publications referenced by this paper.
Showing 1-10 of 38 references

Inactivation of the retinoblastoma susceptibility gene in human breast cancers

Lee, P E.Y.H., +4 authors W. H. Lee
Science • 1988
View 1 Excerpt

SV 40 tumor antigen present in SV 40 - transformed cells and uninfected embryonal carcinoma cells

M. Loeken, I. Bikel, J. Brady

Activated Haras can cooperate with defective simian virus 40 in the transformation of nonestablished rat embryo fibroblasts

S. E. Mole, J. V. Gannon, M. J. Ford, D. P. Lane
J . Virol . • 1987

Replication of SV40 and polyoma virus chromosomes, p. 99-246

M. L. DePamphilis, M. K. Bradley
The Papovaviridae • 1987

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