The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions.

@article{Srinivasan1989TheLT,
  title={The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions.},
  author={Alagarsamy Srinivasan and Keith W. C. Peden and James M. Pipas},
  journal={Journal of virology},
  year={1989},
  volume={63 12},
  pages={5459-63}
}
The large tumor antigen (T antigen) of simian virus 40 is necessary and sufficient for the neoplastic transformation of a number of established cell lines. Mutational analysis has revealed that a biochemical activity residing within the amino-terminal 121 amino acids of T antigen is sufficient to induce the transformation of some cell lines, such as C3H10T1/2. The same domain of the molecule also encodes the transactivation function of T antigen and the ability to complex with the… CONTINUE READING

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