The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of plasmodium falciparum-infected erythrocytes

Abstract

The human malaria parasite Plasmodium falciparum evades host immunity by varying the antigenic and adhesive character of infected erythrocytes. We describe a large and extremely diverse family of P. falciparum genes (var) that encode 200-350 kDa proteins having the expected properties of antigenically variant adhesion molecules. Predicted amino acid sequences of var genes show a variable extracellular segment with domains having receptor-binding features, a transmembrane sequence, and a terminal segment that is a probable submembrane anchor. There are 50-150 var genes on multiple parasite chromosomes, and some are in clustered arrangements. var probes detect two classes of transcripts in steady-state RNA: 7-9 kb var transcripts, and an unusual family of 1.8-2.4 kb transcripts that may be involved in expression or rearrangements of var genes.

DOI: 10.1016/0092-8674(95)90055-1

Extracted Key Phrases

7 Figures and Tables

0100200'97'99'01'03'05'07'09'11'13'15'17
Citations per Year

2,693 Citations

Semantic Scholar estimates that this publication has 2,693 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Su1995TheLD, title={The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of plasmodium falciparum-infected erythrocytes}, author={Xin Su and Virginia M. Heatwole and Samuel P. Wertheimer and Frangoise Guinet and Jacqueline A. Herrfeldt and David S. Peterson and Jeffrey A. Ravetch and Thomas E. Wellems}, journal={Cell}, year={1995}, volume={82}, pages={89-100} }