The language of covalent histone modifications

@article{Strahl2000TheLO,
  title={The language of covalent histone modifications},
  author={B. Strahl and C. Allis},
  journal={Nature},
  year={2000},
  volume={403},
  pages={41-45}
}
  • B. Strahl, C. Allis
  • Published 2000
  • Biology, Medicine
  • Nature
  • Histone proteins and the nucleosomes they form with DNA are the fundamental building blocks of eukaryotic chromatin. A diverse array of post-translational modifications that often occur on tail domains of these proteins has been well documented. Although the function of these highly conserved modifications has remained elusive, converging biochemical and genetic evidence suggests functions in several chromatin-based processes. We propose that distinct histone modifications, on one or more tails… CONTINUE READING
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    References

    SHOWING 1-10 OF 78 REFERENCES
    The histone tails of the nucleosome.
    • 509
    Histone acetylation in chromatin and chromosomes.
    • 152
    Patterns of histone acetylation.
    • 140
    Histone acetylation in chromatin structure and transcription
    • 2,623
    • PDF
    Chromatin disruption and modification.
    • 528
    • PDF
    Gene activation by histone and factor acetyltransferases.
    • S. Berger
    • Medicine, Biology
    • Current opinion in cell biology
    • 1999
    • 152
    Histone deacetylase
    • 175
    Role of histone tails in nucleosome remodeling by Drosophila NURF
    • 138
    • PDF