The landscape of persistent human DNA viruses in femoral bone.

  title={The landscape of persistent human DNA viruses in femoral bone.},
  author={Mari Toppinen and Diogo Pratas and Elina V{\"a}is{\"a}nen and Maria S{\"o}derlund-Venermo and Klaus Hedman and Maria Fernanda Perdomo and Antti Sajantila},
  journal={Forensic science international. Genetics},

The Human Bone Marrow Is Host to the DNAs of Several Viruses

A systematic analysis of the DNAs of 38 viruses in the BM detected viral DNA in 88.9% of the samples, up to five viruses in one individual, and the implications of persistent infections on the engraftment, regenerative capacity, and outcomes of bone marrow transplantation deserve in-depth evaluation.

Torque Teno Virus Primary Infection Kinetics in Early Childhood

TTV primary infections occur mainly after birth, and increase during the first two years with high intra- and interindividual variation in both DNA quantities and virus strains.

Detection of Low-Copy Human Virus DNA upon Prolonged Formalin Fixation

The data suggest that low-copy viral DNAs can be satisfactorily investigated from FFPE specimens, and encourages further examination of historical materials.

Herpesviruses, polyomaviruses, parvoviruses, papillomaviruses, and anelloviruses in vestibular schwannoma.

Findings show frequent persistence of anelloviruses, considered normal virome, in VS, and none of the other viruses showed an extensive presence, thereby suggesting insignificant role in VS.

Survey of Viral Reactivations in Elite Athletes: A Case-Control Study

The replication of persisting viruses as indicators of immune function in elite cross-country skiers after ten months of sustained high- performance exercise is investigated, arguing against impaired viral immunity due to high-performance exercise.

The complexity landscape of viral genomes

A comprehensive landscape of the viral genome’s complexity, identifying the most redundant and complex groups regarding their genome sequence while providing their distribution and characteristics at a large and local scale, and conceive a features-based classification methodology that can accurately distinguish viral genomes at different taxonomic levels without direct comparisons between sequences.

Efficient DNA sequence compression with neural networks

GeCo3, a new genomic sequence compressor that uses neural networks for mixing multiple context and substitution-tolerant context models, is created and benchmarked as a reference-free DNA compressor in 5 datasets.



Bioportfolio: lifelong persistence of variant and prototypic erythrovirus DNA genomes in human tissue.

  • P. NorjaK. Hokynar K. Hedman
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2006
The data suggest strongly that the newly identified human erythrovirus type 2 as well as the prototype 1 circulated in Northern and Central Europe in equal frequency, more than half a century ago, whereafter type 2 disappeared from circulation.

Neolithic and medieval virus genomes reveal complex evolution of hepatitis B

This work reconstructed two Neolithic and one medieval HBV genomes by de novo assembly from shotgun DNA sequencing data and observed HBV-specific peptides using paleo-proteomics, showing that HBV circulates in the European population for at least 7000 years.

Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans

It is shown that B19V has been associated with humans for thousands of years, which is significantly longer than previously thought, and that the virus has been evolving at a rate an order of magnitude lower than estimated previously.

Typing of urinary JC virus DNA offers a novel means of tracing human migrations.

Overall, it appears that JCV genotyping promises to reveal previously unknown human migration routes: ancient as well as recent.

JC Virus Evolution and Its Association with Human Populations

While the estimated nucleotide substitution rate of JCV has large confidence intervals due to limited sampling, the analysis suggests that this virus may evolve nearly two orders of magnitude faster than predicted under the codivergence hypothesis.

HERQ-9 Is a New Multiplex PCR for Differentiation and Quantification of All Nine Human Herpesviruses

HerQ-9, a pan-HHV quantitative PCR designed in triplex reactions to differentiate and quantify each of the HHV-DNAs, is demonstrated to be suitable for the diagnosis of a plethora of herpesvirus-related diseases.

Extinct type of human parvovirus B19 persists in tonsillar B cells

It is shown that B19V DNA is most frequent and abundant among B cells, and within them the authors find a B 19V genotype that vanished from circulation >40 years ago, which supports the maintenance of pathogen-specific humoral immune responses as a consequence of B-cell long-term survival rather than continuous replenishment of the memory pool.

Differential Nuclear and Mitochondrial DNA Preservation in Post-Mortem Teeth with Implications for Forensic and Ancient DNA Studies

A combined genetic and histological examination of DNA content and rates of DNA degradation in the different tooth tissues of 150 human molars over short-medium post-mortem intervals confirmed that targeted sampling of cementum from teeth buried for up to 16 months can provide a reliable source of nuclear DNA for STR-based genotyping using standard extraction methods, without the need for specialised equipment or large-volume demineralisation steps.

Viral epigenetics.

The role of histone modification, nucleosome location, and DNA methylation in regulating the biological consequences of infection and transformation of DNA tumor viruses is slowly becoming better understood.