The landscape of accessible chromatin in mammalian preimplantation embryos

  title={The landscape of accessible chromatin in mammalian preimplantation embryos},
  author={Jingyi Wu and Bo Huang and He Chen and Qiangzong Yin and Yang Liu and Yunlong Xiang and Bingjie Zhang and Bofeng Liu and Qiujun Wang and Weikun Xia and Wenzhi Li and Yuanyuan Li and Jing Ma and Xu Peng and Hui Zheng and Jia Ming and Wenhao Zhang and Jing Zhang and Geng Tian and Feng Xu and Zai Chang and Jie Na and Xuerui Yang and Wei Xie},
In mammals, extensive chromatin reorganization is essential for reprogramming terminally committed gametes to a totipotent state during preimplantation development. However, the global chromatin landscape and its dynamics in this period remain unexplored. Here we report a genome-wide map of accessible chromatin in mouse preimplantation embryos using an improved assay for transposase-accessible chromatin with high throughput sequencing (ATAC-seq) approach with CRISPR/Cas9-assisted mitochondrial… CONTINUE READING