The lactic acid response to alkalosis in panic disorder : an integrative review.

@article{Maddock2001TheLA,
  title={The lactic acid response to alkalosis in panic disorder : an integrative review.},
  author={Richard J. Maddock},
  journal={The Journal of neuropsychiatry and clinical neurosciences},
  year={2001},
  volume={13 1},
  pages={22-34}
}
Panic patients consistently show exaggerated lactic acid response to alkalosis, whether produced by hyperventilation or by sodium lactate infusion. Understanding why this occurs may provide important clues to the pathogenesis of panic disorder. Although brain hypoxia from excessive hypocapnia-induced cerebral vasoconstriction is often cited as the mechanism of elevated brain lactic acid in panic disorder, studies of brain metabolism show that hypocapnia rarely leads to brain hypoxia. Increased… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 81 references

Boron WF: pH regulation in mammalian neurons, in pH and Brain Function, edited by Kaila K, Ransom BR

  • MO Bevensee
  • 1998
Highly Influential
4 Excerpts

Changes in arterial gas tensions, in Cerebral Blood Flow and Metabolism, edited by Edvinsson L, MacKenzie ET

  • L Edvinsson, ET MacKenzie, J McCulloch
  • 1993
Highly Influential
6 Excerpts

Role of hydrogen ions in regulation of cerebral blood flow and other regional flows

  • W Kuschinsky
  • Advances in Microcirculation
  • 1982
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…