The lactic acid response to alkalosis in panic disorder : an integrative review.

  title={The lactic acid response to alkalosis in panic disorder : an integrative review.},
  author={Richard J. Maddock},
  journal={The Journal of neuropsychiatry and clinical neurosciences},
  volume={13 1},
Panic patients consistently show exaggerated lactic acid response to alkalosis, whether produced by hyperventilation or by sodium lactate infusion. Understanding why this occurs may provide important clues to the pathogenesis of panic disorder. Although brain hypoxia from excessive hypocapnia-induced cerebral vasoconstriction is often cited as the mechanism of elevated brain lactic acid in panic disorder, studies of brain metabolism show that hypocapnia rarely leads to brain hypoxia. Increased… CONTINUE READING


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