The lack of correlation between the increased frequency of allele IL-1RN*2 of interleukin-1 receptor antagonist gene in Czech patients with knee osteoarthritis and the markers of cartilage degradation.

@article{Rikov2008TheLO,
  title={The lack of correlation between the increased frequency of allele IL-1RN*2 of interleukin-1 receptor antagonist gene in Czech patients with knee osteoarthritis and the markers of cartilage degradation.},
  author={{\vS}{\'a}rka Rů{\vz}i{\vc}kov{\'a} and Ladislav {\vS}enolt and Jindra Gatterova and Jiri Vencovsky and Karel Pavelka},
  journal={Folia biologica},
  year={2008},
  volume={54 4},
  pages={115-20}
}
Primary OA is a common multifactorial disease with not fully clarified molecular factors influencing the development of the disease. Among factors disturbing the cartilage integrity are cytokines, such as IL-1, which can stimulate proteinases, resulting in the cartilage destruction. In this regard, IL-1RA competing with IL-1 for binding to its receptor may… CONTINUE READING