The l(2)gl homologue of Drosophila pseudoobscura suppresses tumorigenicity in transgenic Drosophila melanogaster.

@article{Trk1993TheLH,
  title={The l(2)gl homologue of Drosophila pseudoobscura suppresses tumorigenicity in transgenic Drosophila melanogaster.},
  author={Istv{\'a}n T{\"o}r{\"o}k and K. Hartenstein and Andreas Kalmes and Ruediger Schmitt and Dennis Strand and Bernard M. Mechler},
  journal={Oncogene},
  year={1993},
  volume={8 6},
  pages={1537-49}
}
Mutations in the tumour-suppressor gene lethal(2)giant larvae (l(2)gl) of Drosophila cause malignant transformation of the optic centres of the larval brain and the imaginal discs. We report the cloning and sequencing of the l(2)gl gene from Drosophila pseudoobscura. Comparison of this sequence with D. melanogaster reveals a significant sequence conservation within the l(2)gl protein-coding domain and a strong sequence divergence in the 5' promoter region and in the introns. The deduced amino… CONTINUE READING

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